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Swedish genetic diseases

Greater severity of covid-19 linked to DNA inherited from

Swedish Offers Genetic Testing Swedish Medical Center

The Genetic Structure of the Swedish Population. PLoS ONE 6(8) (August 4, 2011): e22547. This is a detailed survey of 5174 Swedes from many parts of Sweden. Genome-wide single nucleotide polymorphisms (SNPs) from them were studied. The researchers concluded that the Swedes aren't a homogeneous people. Those in the south of Sweden are closely. Patterns of genetic diversity have previously been shown to mirror geography on a global scale and within continents and individual countries. Using genome-wide SNP data on 5174 Swedes with extensive geographical coverage, we analyzed the genetic structure of the Swedish population. We observed strong differences between the far northern counties and the remaining counties

All NorthShore Medical Group and Swedish Hospital primary care locations offer the GWA. If your physician is not at one of these locations, you can schedule a genetic testing appointment with the Neaman Center for Personalized Medicine, Medical Genetics at 847-570-GENE (4363) The Swedish mutation, or familial Alzheimer's disease genetic mutation, is one of the most well known genetic variations that causes early-onset familial Alzheimer's disease A genetic disorder is a disease caused in whole or in part by a change in the DNA sequence away from the normal sequence. Genetic disorders can be caused by a mutation in one gene (monogenic disorder), by mutations in multiple genes (multifactorial inheritance disorder), by a combination of gene mutations and environmental factors, or by damage to chromosomes (changes in the number or. The strong genetic association of this disease with the C282Y mutation, and the striking prevalence of this mutation in individuals of European ancestry has led researchers to investigate the history of C282Y, including the location in Europe where it first originated and how this mutation eventually spread throughout Europe

Welander distal myopathy, Swedish type Genetic and Rare

  1. If you have neurofibromatosis or a family history of the disorder, you can find a doctor at the Swedish Neurofibromatosis Center. Patients with other tumor genetic syndromes, including von Hippel-Lindau, tuberous sclerosis, Sturge-Weber, Turcot syndrome and Cowden syndrome are also seen in the specialty clinic
  2. Dupuytren's disease (DD) is an ancient affliction of unknown origin. It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried
  3. More surprisingly, genetic variants in the Old Order Amish isolate in Lancaster also differ from those in Big Valley, Pa., and those in Cuyahoga County, Ohio. The Mercer County Amish are among the least genetically characterized Amish communities in the United States, with no catalogue of either genetic disorders or variants seen in the community

Swedish Genetics - DNA of the people of Swede

  1. ary results from our own study of the Swedish Sami.
  2. Identifying the races of Europe and applying specific personality traits to the different regions is certainly not a new idea. The idea that geographical location and genetics plays a huge role in how personality develops. The Scandinavian Personality Traits have been under investigation since the late 1800's. There have been multiple publications that have looked
  3. Author summary Genetic anticipation is a phenomenon where symptoms of a hereditary disease appear at an earlier age and/or are more severe in successive generations. In genetic disorders such as Fragile X syndrome, Myotonic dystrophy type 1 and Huntington disease, anticipation is caused by the expansion of unstable trinucleotide repeats during meiosis
  4. Stem cells A new biobank in Sweden, containing blood samples from patients with Parkinson's disease and age- and sex-matched healthy people — along with data regarding the individuals' lifestyles and medical histories — may help researchers investigate the underlying mechanisms of the neurodegenerative disorder and find new treatments
  5. A genetic continuity is seen between the ancient Corded Ware culture people (who inhabited central and eastern Europe, including the land that's now Poland) and modern Poles and other Slavs. Anna Juras, Miroslawa Dabert, Alena Kushniarevich, Helena Malmström, Maanasa Raghavan, Jakub Z. Kosicki, Ene Metspalu, Eske Willerslev, and Janusz Piontek
  6. According to genetic research, genes for red hair first appeared in human beings about 40,000 to 50,000 years ago. These genes were then brought to the British Isles by the original settlers, men and women who would have been relatively tall, with little body fat, athletic, fair-skinned and who would have had red hair
  7. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease. Results: Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population

Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also associate with Crohn's disease (CD) and/or ulcerative colitis (UC), the two main forms of inflammatory bowel disease (IBD), in Finnish patients COVID-19 is an emerging, rapidly evolving situation. Get the latest public health information from CDC: https://www.coronavirus.gov (link is external) Get the latest research information from NIH: https://covid19.nih.gov (link is external Early studies from the Swedish and Danish twin registries 18,19 found a genetic influence on the risk of death from coronary heart disease in men by comparing concordance between monozygotic and.

Newborn babies are already being screened for mutations and genetic tests help families with hereditary breast cancer. Genomic-driven precision medicine (GDPM) is an emerging approach for disease treatment. Around 30 Swedish researchers suggest a direction forward in a review article in Journal of Internal Medicine (JIM) Patients with tinnitus in the Swedish Hospital Discharge Register (1964-2015), Outpatient Register (2001-2015), and Primary Healthcare Register (1997-2015) were identified by the following International Classification of Diseases (ICD) codes: ICD-7 code 781.32, ICD-8 code 781.31, ICD-9 code 388D, and ICD-10 code H931. There was no primary care.

Inherited Disease - In about 80% of suspected cases for genetic disease, PCR has replaced conventional diagnostic methods for determining hemophilia, alpha -1- antitrypsin deficiency, phenylketonuria, cystic fibrosis, and Duchennes muscular dystrophy. In the future, PCR technology will make it possible for more comprehensive genetic. Adam Ameur et al. SweGen: a whole-genome data resource of genetic variability in a cross-section of the Swedish population, European Journal of Human Genetics (2017). DOI: 10.1038/ejhg.2017.13 This test is most relevant for people of Swedish descent. Test performance summary ZSS is a group of rare genetic disorders. The form of ZSS covered by this report is characterized by impaired hearing, vision, and organ function, as well as developmental disability and early death. A person must have two variants in the PEX1 gene in order.

Some genetic loci may affect susceptibility to multiple immune system-related diseases. In the current study, we investigated whether the known susceptibility loci for celiac disease (CelD) also. Parkinson's Risk. And then there were more serious associations between predicted genetic ancestry and certain diseases. Using data from thousands of 23andMe customers of European descent, our researchers found that ancestry may be important in determining the risks for Parkinson's disease and for basal cell carcinoma, the most common type of skin cancer With different populations of cats in different parts of the world, some genetic disorders may be seen in more commonly, or even exclusively, in some geographical locations. However, with international travel of both owners and cats, many disorders are seen worldwide (although the frequency of disease may vary in different regions) The relationship between the genetic and environmental risk factors for alcohol use disorders (AUD) detected in Swedish medical, pharmacy, and criminal registries has not been hitherto examined. Prior twin studies have varied with regard to the detection of shared environmental effects and sex differences in the etiology of AUD In order for an autosomal recessive disorder to develop may also include the possibilities of using preimplantation (for example cystic fibrosis (CF), spinal muscular atrophy genetic diagnosis, donor sperm or oocytes, seeking adop- (SMA), thalassemia, and sickle cell disease), the abnormal tion—or refraining from having children (3,4). gene.

Video: The Genetic Structure of the Swedish Populatio

Epilepsy Neurology. Family Medicine. Family Medicine Obstetrics. Foot and Ankle Orthopedic Surgery. Foot and Ankle Surgery. Gastroenterology. Gastrointestinal Motility Disorders. General Surgery NEW YORK — Tataa Biocenter said on Wednesday that it has acquired a majority stake in Swedish genetic testing provider Life Genomics. Life Genomics, which was spun off from Gothenburg-based Tataa in 2014, offers Roche's Harmony noninvasive prenatal test (NIPT) for chromosomal abnormalities, a genetic disease carrier test, and a test for Alzheimer's disease risk Dr. Daniel Kastner of the US National Institutes of Health identified 16 rare autoinflammatory genetic disorders and found effective treatments for at least 12 of them. In the process, he.

Milk Does Not Do A Body Good – New Study Says – Conquer

Northern and southern Swedes are genetically different

Swedish Association of Rare Disorders - NORD (National

Comprehensive genetic medicine care The Genetic Medicine Clinic at UW Medical Center - Montlake is the only genetics clinic for adults in the Pacific Northwest that offers the full range of evaluation, diagnosis, assessment, genetic testing and interpretation, counseling and care management for all genetic and genomic disorders. We also offer resource referrals to individuals who have genetic. Earlier this year, two scientists won the Nobel Prize for a discovery The Royal Swedish Academy of Sciences called genetic scissors.It was the development of a method for genome editing A genomic revolution is poised to cure sickle cell and other genetic diseases. By Carolyn Barber on July 17, 2021; Share on Facebook. the secretary-general of the Royal Swedish Academy of. Swedish Vallhund Temperament and Personality. Meet the classic big dog in a small body. The Swedish Vallhund is smart, alert, and energetic, all in a compact, agile package that makes him a good choice for the family who will enjoy his lively spirit, sense of humor, and versatile abilities The bulk of risk, or liability, for autism spectrum disorders (ASD) was traced to inherited variations in the genetic code shared by many people. These and other (unaccounted) factors dwarfed contributions from rare inherited, non-additive and spontaneous (de novo) genetic factors. Population-Based Autism Genetics and Environment Stud

The genetic origin of the Sámi people is complex and difficult to trace. Their beginnings are closely linked with the origin of the Finns. Both groups speak a Finno-Ugric language that causes them to be singled out among their Indo-European neighbors and associated historically with each other An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B - Full Text View Genetic disorders are diseases that are caused by an abnormality in the genome. Abnormalities can range from a small mutation in a single gene to the addition or subtraction of an entire chromosome or set of chromosomes. Most Genetic disorders are present from birth and are quite rare, often affecting only one person in every several thousand. For each disorder, we assumed that the random effects are independent between families, but dependent within families ().The model includes cross-disease covariances: σ szbpa is the additive-genetic covariance of schizophrenia and bipolar effect and, similarly, σ szbpf and σ szbpc are the covariances of adult and childhood environmental effects. All parameters were estimated simultaneously. AUD was defined from ICD codes for main and secondary diagnoses from Swedish medical and mortality registries for the following diagnoses: ICD9: alcohol-related psychiatric disorders (291), alcohol dependence (303), alcohol abuse (305A), alcohol-related polyneuropathy (357F), alcohol-related cardiomyopathy (425F), alcohol-related gastritis.

The Finnish Disease Heritage and Other Genetic Isolates Sc

  1. Little genetic evidence exists to justify grouping Hashimoto thyroiditis (HT) and Graves disease (GD) as a single autoimmune thyroid disease. These findings from a national health twin registry were published in The Journal of Clinical Endocrinology and Metabolism.. Data from the Swedish Twin Registry were analyzed for this study
  2. e a person's risk of developing a genetic disease or to deter
  3. The increased risk was largely explained by underlying genetic factors that contributed both to ADHD and the physical disease, with the exception of nervous system disorders and age-related diseases

Finnish heritage disease - Wikipedi

Genetic testing has become both cheaper and more reliable. It is now possible to screen for up to 1,500 genetic disorders and conditions. Ranging from severe conditions like beta thalassemia. Getting the conclusive lead with investigative genetic genealogy — A successful case study of a 16 year old double murder in Sweden. The technology using DNA-based genealogy that solved a double murder in Linköping opens completely new possibilities in investigating serious crime.Linköping University researchers are now involved in spreading new knowledge about the technology, which brings.

Similar to molecular genetic studies, we showed evidence that schizophrenia and bipolar disorder partly share a common genetic cause. These results challenge the current nosological dichotomy between schizophrenia and bipolar disorder, and are consistent with a reappraisal of these disorders as distinct diagnostic entities To examine the association between low birth weight (LBW) and cardiometabolic diseases (CMDs, including heart disease, stroke and type 2 diabetes mellitus) in adulthood, and to explore whether genetic, early-life environmental and healthy lifestyle factors play a role in this association. A population-based twin study The most common genetic disease of this sort is phenylketonuria, an autosomal recessive disease with a maximum frequency of 1 in 10,000 births. Most other inborn errors of metabolism have frequencies between 1 in 40,000 and 1 in 250,000 (Vogel and Motulsky, 1986) Our genetic specialists are experts at diagnosing common and rare inherited skin disorders based on clinical exams, family history and genetic testing. Epidermolysis bullosa diagnosis. This is a group of rare inherited skin diseases that cause fragile, blistering skin in response to minor injury or friction

2,548 words. The 2020 Nobel Prize in Chemistry was awarded to two women who pioneered a new genetic technology that has captured the public imagination and revolutionised science. Kevin Davies tells the story of how CRISPR changed the future in less than a decade. When the international phone call came, at precisely 2:53 am Pacific time, the. Pettersson E, Larsson H, Lichtenstein P. Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population. Mol Psychiatry. 2016;21:717-21 Swedish registries have provided a tremendous resource for the study of the epidemiology and genetic epidemiology of psychiatric disorders [9,10,11,12,13,14]. However, up until now, the ascertainment of individuals with psychiatric disorders has been restricted to hospital-based diagnoses using the Hospital Discharge Register and specialist out. Lifestyle affects life expectancy more than genetics, Swedish study finds. Date: February 8, 2011. Source: University of Gothenburg. Summary: How long your parents lived does not necessarily.

Genetic Testing Primary Care Swedish Hospital Part

Batten disease is an inherited genetic disorder that appears to affect the function of tiny bodies within cells called lysosomes. Lysosomes are the recycle bin of the cell and regularly break down waste, proteins, and naturally occurring fatty compounds called lipids into smaller components that can be discarded out of the cell or. Chromosomal Syndromes and Genetic Disease Frederick W Luthardt,Swedish Hospital Medical Center, Seattle, Washington, USA Elisabeth Keitges,Dynacare University Of Washington Understanding Modes of Inheritance Genetic diseases are either single-gene or multifactorial, Modes of Inheritance X-linked recessive disorders are disorders in. Because these diseases are caused by combinations of genetic and non-genetic exposures, GDPM models that combine clinical data, PRS, biomarkers (including large-scale omics data) and exposure information are likely to improve risk prediction or aid treatment decisions (e.g. the 'Stockholm 3' prostate cancer algorithm ). However, even when. Kidney Disorders and Conditions. While most renal disorders are not hereditary, some kidney conditions have known inherited genetic components. Common hereditary kidney disorders include: Autosomal Dominant Polycystic Kidney Disease, a generally late-onset condition that leads to progressive cyst development Enclosed pictures and maps show the common genetic origin of all Slavs. Slavs are not only a nation, but a unique race of people. Therefore: Anti-Slavicism is racism! Some studies came to the conclusion that R1a may have arisen 15,000 years ago in the vicinity of Ukraine, possibly expanding from either the Ukrainian LGM refuge following the end.

Genetic and environmental factors in polymyalgia rheumatica. Dr M A Cimmino, Cattedra di Reumatologia, DIMI, Viale Benedetto XV 6, 16132 Genova, Italy. Polymyalgia rheumatica (PMR) is a disease that rheumatologists feel confident in recognising in their daily practice. In the classic form, its diagnosis is straightforward and standard. Soybean Genetic Treasure Trove Found in Swedish Village By Don Comis July 29, 2011. The first screening by U.S. Department of Agriculture (USDA) scientists of the American ancestors of soybeans for tolerance to ozone and other stresses had an eye-opening result: The world superstars of stress resistance hailed from a little village in far northern Sweden, called Fiskeby Malmgren B. Clinical, histopathologic, and genetic diagnosis in osteogenesis imperfecta and dentinogenesis imperfecta. Thesis, Karolinska Institutet, Stockholm, 2004. 16. Witkop CJ Jr. Manifestations of genetic diseases in the human pulp. Oral Surg Oral Med Oral Pathol. 1971;32(2):278-316. Article PubMed Google Schola

Breaking Taboo, Swedish Scientist Seeks To Edit DNA Of Healthy Human Embryos. Nonetheless, the work is setting off alarm bells among critics around the world. Couples carrying genetic diseases. Bipolar disorder (also known as manic depressive illness) is a complex genetic disorder in which the core feature is pathological disturbance in mood (affect) ranging from extreme elation, or mania, to severe depression usually accompanied by disturbances in thinking and behaviour. The lifetime prevalence of 1% is similar in males and females and family, twin, and adoption studies provide. Genetic map of Scotland revealed. The DNA of Scottish people still contains signs of the country's ancient kingdoms, with many apparently living in the same areas as their ancestors did more than a millennium ago, a study shows. Experts have constructed Scotland's first comprehensive genetic map, which reveals that the country is divided.

1. Introduction. The etiology of Parkinson's disease (PD) is considered to be complex and to involve both genetic and environmental factors. Mutations have been identified in several genes in families with autosomal dominant or recessive PD, and multiple susceptibility genes have been reported (Lesage and Brice, 2009).Familial aggregation studies have consistently shown that having a relative. The domestic dog is frequently cited as being an exceptional model for human inherited disorders due to the number of diseases identified, similarity in disease presentation, and population structure in the dog [].The ability to record health data for defined breeds has simultaneously permitted genetic dissection of particular disorders and bolstered the implicit assumption that purebred dogs. The aim of this study was to analyse the contribution of genetic and environmental factors to susceptibility for DD in a large population-based sample of twins. Materials and Methods. The Swedish Twin Registry (STR) was established at Karolinska Institutet in the end of the 1950′s and is considered to be the largest of its kind in the world Here at Gaylan's, we take the reduction of the rate and severity of genetic diseases in goldens as an important part of our role as breeders. On this rather lengthy page, we lay out our priorities, production rates, and thoughts on the health issues facing goldens.We hope this information will be helpful to golden buyers and owners, regardless of where they get their dogs Swedish Orphan Biovitrum is a Swedish company engaged in the research, production and distribution of treatments dedicated to rare diseases. An example of a genetic metabolic disease is.

All About Swedish Lapphund Dog Breed – Origin, BehaviorGM plant grows insect sex pheromone compounds needed for

AIMS: Some 15% of the Swedish population is born outside Sweden, originating from all continents of the world. Thalassemia and sickle cell anemia constitute the most common inherited recessive disorders globally and they are endemic in areas of Africa and Asia, origins of many immigrants to Sweden. We aimed at investigating the origins of the Swedish sickle cell and thalassemia patients. The scientists will split the prize money of 10 million Swedish kronor, or a little more than $1.1 million. so genetic eye diseases and blood illnesses such as sickle cell disease are most. Based on the symptoms, modern researchers concluded that the royals suffered from hemophilia--a genetic disease that prevents blood from clotting--but there was never any concrete evidence Linnaeus, the 18th-century Swedish scientist known for categorizing creatures into genus and species, also developed a taxonomy of disease. One area that might benefit from genetic disease.

Swedish mutation - Wikipedi

Genetic Diseases in Cattle. By: Lorianna Keuhn and Tyler Olson. As the field of genetics has advanced, new undesirable haplotypes have been discovered. Among these are fertility haplotypes and congenital defects. As genotyping has become more prevalent on farms, the question of what to do with carriers of these haplotypes has arisen Genetic anticipation is a phenomenon in which the signs and symptoms of genetic conditions become more severe and/or appear at an earlier age, as they are passed from one generation to the next. Some scientists have suggested this disease could have been smallpox or even bubonic plague but bubonic plague is a bacterial disease rather than a virus and is not blocked by the CCR5-Ä32 mutation Genetic screening tests involve identifying changes in chromosomes, genes or proteins, which can help provide insight into the development of diseases caused by genetic traits passed from generation to generation. Genetic testing allows us to analyze your DNA to confirm or rule out a suspected genetic condition or assess your risk of developing.

Genetic Disorders - Genome

In a recent Swedish study, extensive loss of genetic variation and moderate levels of recent inbreeding did not appear to be a main cause of poor health in a number of pedigree dog breeds . In another study, there was little correlation between current levels of inbreeding or reduced heterozygosity and prevalence of genetic disease . One. Genetic testing is also available for other forms of hereditary dementia, for example Creutzfeldt-Jakob disease and frontotemporal dementia, as well as for some forms of inherited Parkinson disease. The specific details differ for each disease, depending on its underlying genetics, but the general issues are similar The disorders in Table 4 sort into two categories: (1) mental disorders that are ready for and require a large NIMH Genetics Initiative and (2) mental disorders that would benefit from nonmolecular genetic and/or epidemiological studies and smaller scale molecular approaches to better document their estimated heritability

Modern genetic analysis has revealed genetic differentiation across the south of Britain and Ireland. This structure demonstrates the impact of hegemonies and migrations from the histories of Britain and Ireland. How this structure compares to the north of Britain, Scotland, and its surrounding Isles is less clear. We present genomic analysis of 2,544 British and Irish, including previously. disease {noun} Their quick reaction contributed considerably to the containment of this disease. expand_more Deras snabba respons bidrog i hög grad till att hejda spridningen av denna sjukdom. It ought not, however, to be regarded, as it is in the report, as a chronic disease In this cohort study involving 4,129,002 people (51.4% male) with a mean (SD) age at follow-up of 45.5 (13.4) years, experts aspired to explore whether family genetic risk scores (FGRSs), calculated for the entire Swedish population, can elucidate the genetic relationship between major affective and psychotic disorders and clarify the relationship of genetic risk with important clinical. genetic disease. Need antonyms for genetic disease? Here's a list of opposite words from our thesaurus that you can use instead. Noun. Opposite of inherited disorder. acquired disease. acquired disorder. acquired infection. nosocomial infection Year Paper Type PMID PMCID Journal Title 2019 PrimaryAnalysis 31886626 pending American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Genome-wide association study of shared liability to anxiety disorders in Army STARRS. 2019 SecondaryAnalysis 31852892 PMC6920448 Nature communications Genetic.

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About The Disease - Genetic Ties To Viking Ancestry

genetic disorders are presented in Table 1. Disorders have been chosen according to Online Mendelian Inheritance in Animals catalogue (OMIA) records by such categories as known key mutation, commonly known and used beef breeds, number of publications referring to autosomal recessive disorders inherited among beef cattle, number o Cluster, Genetic Trends Observed in Autoimmune Diseases. An assessment of the world's largest twin registry found telling patterns of common autoimmune diseases including type 1 diabetes. A new assessment of the world's largest twin registry found that autoimmune diseases commonly cluster in patients, and are frequently influenced by genetics Our veterinary laboratory provides a complete range of diagnostic tests for veterinary surgeons, breeders, sanctuaries, zoos, universities, laboratories, state departments and animal owners throughout Europe. Since 1989, Laboklin has been providing wide array of diagnostic services in the areas of genetics, haematology, serology, microbiology, pathology, allergy, hygiene and molecular biology If the mode of inheritance for the disease is recessive, yes you can. Simply put, if you breed an affected dogs (two copies of the mutation) to one you want to determine the genetic status for, if you get at least six puppies clear of the disease it is at least 98% likely that the dog you were testing is clear

(PDF) The influence of genetic origin and its interaction

Doberman DCM is a genetic disease of a heart muscle which becomes progressively weak and eventually leads to heart failure. Dogs literally drop dead. DCM is the main reason for decreased longevity in the breed. It is suspected that about 70% of Dobermans worldwide are affected by this disease (as of 2017) The results show that dental disorders are common among Swedish commercial sows and different from those found in female wild boars in Sweden [ 1 ]. The domestic sows from commercial pig herds had some disorders that may be of genetic origin (e.g. supernumerary teeth, absence of teeth, malalignment) and which were uncommon in wild boars Streptococcus agalactiae , also designated group B streptococcus (GBS), is an important pathogen in neonates, pregnant women, and nonpregnant adults with predisposing conditions. We used multilocus sequence typing (MLST) to characterize 158 GBS isolates that were associated with neonatal and adult invasive disease and that were collected in northern and western Sweden from 1988 to 1997 Myasthenia gravis (MG) is a chronic neuromuscular autoimmune disease that causes skeletal muscles to weaken, particularly after strenuous activity. The muscles in the eyelids and those attached to the eyeball are commonly the first (and sometimes only) muscles affected in myasthenia gravis. Other muscles that may become weak include jaw, limb.